Yap1 Polyclonal Antibody for Rat(Rattus norvegicus) | EIAab.comYap1 Polyclonal Antibody for Rat(Rattus norvegicus)

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Yap1 (Gene name),

Yorkie homolog (Protein name ), YAP1_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Yap1(Yap;Yap65);

Protein name:

Yorkie homolog;

Alternative:

65 kDa Yes-associated protein(YAP65);

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Binds to the SH3 domain of the YES kinase. Binds to WBP1 and WBP2. Binds, in vitro, through the WW1 domain, to neural isoforms of ENAH that contain the PPSY motif. The phosphorylated form interacts with YWHAB. Interacts (via WW domains) with LATS1 (via PPxY motif 2). Interacts with LATS2. Interacts (via WW domain 1) with isoform 2 of ERBB4 (via PPxY motif 2). Interacts with TEAD1, TEAD2, TEAD3 and TEAD4 (By similarity). Interacts with TP73 (By similarity). Interacts with RUNX1.

Function:

Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction (By similarity). Isoform 2, isoform 3 and isoform 4 (lacking the C-terminal transactivation domain) can attenuate p73-mediated cell death signaling in transcriptional repression-induced atypical death (TRIAD) of neurons.

Subcellular Location:

Cytoplasm Nucleus Both phosphorylation and cell density can regulate its subcellular localization. Phosphorylation sequesters it in the cytoplasm by inhibiting its translocation into the nucleus. At low density, predominantly nuclear and is translocated to the cytoplasm at high density.

Protein Attributes:

Sequence length:

469

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

469:

VESVLAATKL | DKESFLTWL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q2EJA0

STRING:

10116.ENSRNOP00000034369

KEGG:

rno:363014

UniGene:

Rn.162978

Pfam:

PF00397

String:

Q2EJA0

Uniprot:

Q2EJA0

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ELISA Kit for Rat Yorkie homolog

Cat.:

E15210m

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MSDS:

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Packing:

96T

ELISA Kit for Rat Yorkie homolog

Cat.:

E15210h

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Manual:

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Packing:

96T

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ELISA Kit for Rat Yorkie homolog

Cat.:

E15210r

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Packing:

96T

ELISA Kit for Rat Yorkie homolog

Cat.:

E15210c

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MSDS:

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Packing:

96T

CLIA Kit for Rat Yorkie homolog

Cat.:

U15210r

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MSDS:

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Packing:

96T

CLIA Kit for Rat Yorkie homolog

Cat.:

U15210m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Rat Yorkie homolog

Cat.:

U15210h

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MSDS:

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Packing:

96T

CLIA Kit for Rat Yorkie homolog

Cat.:

U15210c

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MSDS:

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Packing:

96T

Polyclonal Antibody for Rat Yorkie homolog

Cat.:

P15210Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat Yorkie homolog

Cat.:

P15210Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat Yorkie homolog

Cat.:

P15210Rb-m

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat Yorkie homolog

Monoclonal Antibody for Rat Yorkie homolog

Protein for Rat Yorkie homolog

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Transcriptional repression induces a slowly progressive atypical neuronal death associated with changes of YAP isoforms and p73."
Hoshino M. , Qi M.-L. , Yoshimura N. , Tagawa K. , Wada Y.-I. , Enokido Y. , Marubuchi S. , Harjes P. , Arai N. , Oyanagi K. , Blandino G. , Sudol M. , Rich T. , Kanazawa I. , Wanker E.E. , Saitoe M. , Okazawa H.
J. Cell Biol.172:589-604(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4);FUNCTION;INDUCTION;TISSUE SPECIFICITY
strain: Wistar.
2.

"Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
Hoffert J.D. , Pisitkun T. , Wang G. , Shen R.-F. , Knepper M.A.
Proc. Natl. Acad. Sci. U.S.A.103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-94 AND THR-95;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]

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